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The rising of multi-resistant bacterial pathogens is currently one of the most critical threats to global health and requires urgent actions for its control and a better understanding of the origin, evolution, and spread of antibiotic resistance. It is of consensus that this must be faced under a one-health prism that includes the environment and non-human animals as possible sources and media for resistance amplification and evolution. In this regard, the resistome extension and diversity present in natural and remote environments remain largely unexplored. Moreover, little is known about the availability of antimicrobial resistance genes (ARGs) from these environments to be disseminated through horizontal transfer, potentially mediating the rise of new resistance mechanisms among clinically relevant pathogenic microorganisms. Furthermore, the impact of the anthropogenic intervention on the presence of antibiotic resistant bacteria and the underlying genes is still a matter of controversy. In this context, the Antarctic Peninsula soils are attractive remote environments to study, since their high microbial diversity, the presence of ice-covered soils sheltering ancestral microorganisms that are being exposed as cause of the global warming, and because it is one of the most transited routes between Antarctica and the rest of the world, thus permitting genetic and microbial carriage among those places. Also, it harbors both human bases and places without noticeable human intervention. In this work, we explored the culturable resistome of soils from different places of North Antarctica, including human bases and non-intervened areas. We identified bacterial …