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(57) ABSTRACT A fiber optic needle probe for measuring or imaging the internal Structure of a Specimen includes a needle defining a bore, an optical fiber Substantially positioned within the bore, and a beam director in optical communication with the optical fiber. At least a portion of the wall of the needle is capable of transmitting light. The beam director directs light from the optical fiber to an internal Structure being imaged and receives light from the Structure through a transparent portion of the wall. An actuating device causes motion of any, or all of, the needle, optical fiber, and beam director to Scan the internal Structure of the Specimen. The fiber optic needle probe allows imaging inside a Solid tissue or organ without intraluminal insertion. When used in conjunction with an OCT imaging System, the fiber optic needle probe enables tomographic imaging of the microstructure of inter nal organs and tissueS …