作者
Jun Yu, Sui Zhang, Eagle SH Chu, Minnie YY Go, Rebecca HY Lau, Junhong Zhao, Chung-Wah Wu, Lixin Tong, Jingmin Zhao, Terence CW Poon, Joseph JY Sung
发表日期
2010/6/1
期刊
The international journal of biochemistry & cell biology
卷号
42
期号
6
页码范围
948-957
出版商
Pergamon
简介
Nonalcoholic steatohepatitis with fibrosis is a more severe form of nonalcoholic fatty liver disease, one of the most common liver diseases. We have previously shown that peroxisome proliferator-activated receptors gamma (PPARγ) ligand, rosiglitazone, prevented the development of the methionine choline deficient (MCD) diet-induced fibrosing steatohepatitis. We have now tested whether overexpression of PPARγ ameliorates established steatohepatitis and fibrosis. Male C57BL6 mice fed with MCD diet for 8 weeks developed hepatic fibrosis with increased hepatic expression of collagen1α(I), inhibitors of fibrosis reversal-1, regulator involved in matrix degradation-9 and connective tissue growth factor. After 2 weeks of transduction of PPARγ through an adenovirus-expressing PPARγ (Ad-PPARγ), expression of these genes was reduced in a manner that paralleled the reduction in activated hepatic stellate cells …
学术搜索中的文章
J Yu, S Zhang, ESH Chu, MYY Go, RHY Lau, J Zhao… - The international journal of biochemistry & cell biology, 2010