作者
Matteo Bertini, Nina Ajmone Marsan, Victoria Delgado, Rutger J van Bommel, Gaetano Nucifora, C Jan Willem Borleffs, Giuseppe Boriani, Mauro Biffi, Eduard R Holman, Ernst E van der Wall, Martin J Schalij, Jeroen J Bax
发表日期
2009/9/29
期刊
Journal of the American College of Cardiology
卷号
54
期号
14
页码范围
1317-1325
出版商
American College of Cardiology Foundation
简介
Objectives
This study explored the effects of cardiac resynchronization therapy (CRT) on left ventricular (LV) twist, particularly in relation to LV lead position.
Background
LV twist is emerging as a comprehensive index of LV function.
Methods
Eighty heart failure patients were included. Two-dimensional echocardiography was performed at baseline, immediately after CRT, and at 6-month follow-up. Speckle-tracking analysis was applied to assess LV twist. The LV lead was placed preferably in a (postero)lateral vein, and at fluoroscopy, the position was classified as basal, midventricular, or apical. Response to CRT was defined as reduction of LV end-systolic volume ≥15% at 6-month follow-up. A control group comprised 30 normal subjects.
Results
Peak LV twist in heart failure patients was 4.8 ± 2.6° compared with 15.0 ± 3.6° in the control subjects (p < 0.001). At 6-month follow-up, peak LV twist significantly improved …
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M Bertini, NA Marsan, V Delgado, RJ van Bommel… - Journal of the American College of Cardiology, 2009