作者
James W Lillard, Prosper N Boyaka, Dennis D Taub, Jerry R McGhee
发表日期
2001/1/1
期刊
The Journal of Immunology
卷号
166
期号
1
页码范围
162-169
出版商
American Association of Immunologists
简介
RANTES is produced by lymphoid and epithelial cells of the mucosa in response to various external stimuli and is chemotactic for lymphocytes. The role of RANTES in adaptive mucosal immunity has not been studied. To better elucidate the role of this chemokine, we have characterized the effects of RANTES on mucosal and systemic immune responses to nasally coadministered OVA. RANTES enhanced Ag-specific serum Ab responses, inducing predominately anti-OVA IgG2a and IgG3 followed by IgG1 and IgG2b subclass Ab responses. RANTES also increased Ag-specific Ab titers in mucosal secretions and these Ab responses were associated with increased numbers of Ab-forming cells, derived from mucosal and systemic compartments. Splenic and mucosally derived CD4+ T cells of RANTES-treated mice displayed higher Ag-specific proliferative responses and IFN-γ, IL-2, IL-5, and IL-6 production than …
引用总数
学术搜索中的文章
JW Lillard, PN Boyaka, DD Taub, JR McGhee - The Journal of Immunology, 2001