作者
Cristina Razquin, Estefanía Toledo, Clary B Clish, Miguel Ruiz-Canela, Courtney Dennis, Dolores Corella, Christopher Papandreou, Emilio Ros, Ramon Estruch, Marta Guasch-Ferré, Enrique Gómez-Gracia, Montserrat Fitó, Edward Yu, José Lapetra, Dong Wang, Dora Romaguera, Liming Liang, Angel Alonso-Gómez, Amy Deik, Mónica Bullo, Lluis Serra-Majem, Jordi Salas-Salvadó, Frank B Hu, Miguel A Martínez-González
发表日期
2018/12/1
期刊
Diabetes care
卷号
41
期号
12
页码范围
2617-2624
出版商
American Diabetes Association
简介
OBJECTIVE
Specific lipid molecular changes leading to type 2 diabetes (T2D) are largely unknown. We assessed lipidome factors associated with future occurrence of T2D in a population at high cardiovascular risk.
RESEARCH DESIGN AND METHODS
We conducted a case-cohort study nested within the PREDIMED trial, with 250 incident T2D cases diagnosed during 3.8 years of median follow-up, and a random sample of 692 participants (639 noncases and 53 overlapping cases) without T2D at baseline. We repeatedly measured 207 plasma known lipid metabolites at baseline and after 1 year of follow-up. We built combined factors of lipid species using principal component analysis and assessed the association between these lipid factors (or their 1-year changes) and T2D incidence.
RESULTS
Baseline lysophosphatidylcholines and …
学术搜索中的文章
C Razquin, E Toledo, CB Clish, M Ruiz-Canela… - Diabetes care, 2018