作者
Ana C Takakura, Bárbara F Barna, Josiane C Cruz, Eduardo Colombari, Thiago S Moreira
发表日期
2014/3/1
期刊
Experimental Physiology
卷号
99
期号
3
页码范围
571-585
简介
New Findings
- What is the central question of this study?This study was designed to investigate whether the Phox2b‐expressing neurons in the retrotrapezoid nucleus are important to breathing and chemoreflexes in conscious rats.
- What is the main finding and its importance?The high rate of destruction of a defined cell population (Phox2b+TH−) of the retrotrapezoid nucleus by the toxin suggests that the specialized connectivity of retrotrapezoid nucleus neurons, their glutamatergic nature and their relatively high sensitivity to CO2 are determinant factors in explaining their large contribution to the central and peripheral chemoreflexes.
Chemoreception is the classic mechanism by which the brain regulates breathing in response to changes in tissue CO2/H+. A brainstem region called the retrotrapezoid nucleus (RTN) contains a population of Phox2b‐expressing glutamatergic neurons that appear to function as …
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AC Takakura, BF Barna, JC Cruz, E Colombari… - Experimental Physiology, 2014