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Aspirin is generally used in the prevention of thrombotic occlusive events such as coronary heart disease and stroke. Underlying mechanism of action is that aspirin inhibits platelets by irreversibly inactivating cyclooxygenase-1, thereby blocking the generation of thromboxane A2 which is a potent vasoconstrictor and platelet agonist. Aspirin may also help to decrease the progression of atherosclerosis by its antioxidant effect in addition to its inhibiting effect on the coagulation system. The aim of this study was to examine the antioxidant effect of low-dose aspirin supplementation in a short term period. Ten healthy volunteers were enrolled in the study. Low-dose aspirin (300 mg. daily for 10 days) was given orally to subjects. Serum specimens were taken after 12-14 hr fasting as baseline and at 4th hr and 10th day of the oral aspirin supplementation. Serum total antioxidant activity (AOA), ferritin, iron, total cholesterol, LDL cholesterol, HDL cholesterol and triglycerides were measured. Serum AOA at 4th hr were found significantly higher in comparison to baseline levels (p= 0.006), but no significant difference was determined on the 10th day. There were no significant differences among baseline, 4th hr and 10th day values for the remaining parameters. Our results suggest that low-dose aspirin supplementation rapidly increases total antioxidant activity. Aspirin may play a role in improving the general antioxidative potency of the body.