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Breast cancer is characterized by overexpression of superoxide dismutase (SOD) and downregulation of catalase and more resistance to hydrogen peroxide (H₂O₂) than normal cells. Thus, relatively high H₂O₂ promotes breast cancer cell growth and proliferation. However, excessive intracellular H₂O₂ leads to death of breast cancer cells. In cancer cells, high level ascorbic acid (Asc) is able to be autoxidized and thus provides an electron to oxygen to generate H₂O₂. In the present study, we demonstrated that triethylenetetramine (TETA) enhances Asc autoxidation and thus elevates H₂O₂ production in MCF‐7 cells. Furthermore, Asc/TETA combination significantly impaired cancer cell viability, while having much milder effects on normal cells, indicating Asc/TETA could be a promising therapy for breast cancer. Moreover, SOD1 and N‐acetyl‐L‐cysteine failed to improve MCF‐7 cells viability in the presence of Asc …