查看文章

While a great deal of work has been reported on innate and adaptive white blood cells infiltrating solid tumors, as well as the pre-metastatic niche, there is a paucity of information concerning the early innate immune response to primary tumors. This is particularly evident in the very early stages; before a solid tumor is palpable. Here we used a gelatin sponge model to investigate white blood cells infiltrating a tumor site 12–72 hours following injection. Initial studies focused on identifying the total number of infiltrating cells as well as the number of lymphocytes, macrophages and granulocytes. While 12 hours after injection there was no difference in the total number of cells infiltrating the tumor site versus a control site injected with saline, at 24 and 48 hours there was a small, yet significant increase in the number of cells at the tumor site. The majority of the cells to arrive at the tumor and saline injected sites within the …