作者
Bert Bammens, Pieter Evenepoel, Kristin Verbeke, Yves Vanrenterghem
发表日期
2003/12/1
期刊
Kidney international
卷号
64
期号
6
页码范围
2238-2243
出版商
Elsevier
简介
Removal of middle molecules and protein-bound solutes by peritoneal dialysis and relation with uremic symptoms.
Background
Current guidelines for peritoneal dialysis adequacy are based on kinetics of small water-soluble molecules and do not consider the role of other compounds such as middle molecules and protein-bound solutes. Information on the elimination characteristics of the latter solutes by peritoneal dialysis is limited. Moreover, their relation with uremic symptoms remains unclear. The aim of the present study was (1) to investigate the relative contribution of residual renal function to the overall clearances of β2-microglobulin (β2m), a middle molecule, and p-cresol, a protein-bound solute, in adults on peritoneal dialysis as compared to small water-soluble molecules and (2) to evaluate relations between serum levels and uremic symptoms.
Methods
We performed a cross-sectional observational study …
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B Bammens, P Evenepoel, K Verbeke… - Kidney international, 2003