作者
Martino Belvederi Murri, Davide Prestia, Valeria Mondelli, Carmine Pariante, Sara Patti, Benedetta Olivieri, Costanza Arzani, Mattia Masotti, Matteo Respino, Marco Antonioli, Linda Vassallo, Gianluca Serafini, Giampaolo Perna, Maurizio Pompili, Mario Amore
发表日期
2016/1/1
来源
Psychoneuroendocrinology
卷号
63
页码范围
327-342
出版商
Pergamon
简介
Objectives
To provide a quantitative and qualitative synthesis of the available evidence on the role of Hypothalamic–Pituitary–Adrenal (HPA) axis in the pathophysiology of Bipolar Disorder (BD).
Methods
Meta-analysis and meta-regression of case-control studies examining the levels of cortisol, ACTH, CRH levels. Systematic review of stress reactivity, genetic, molecular and neuroimaging studies related to HPA axis activity in BD.
Results
Forty-one studies were included in the meta-analyses. BD was associated with significantly increased levels of cortisol (basal and post-dexamethasone) and ACTH, but not of CRH. In the meta-regression, case-control differences in cortisol levels were positively associated with the manic phase (p = 0.005) and participants’ age (p = 0.08), and negatively with antipsychotics use (p = 0.001). Reviewed studies suggest that BD is associated with abnormalities of stress-related molecular …
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MB Murri, D Prestia, V Mondelli, C Pariante, S Patti… - Psychoneuroendocrinology, 2016