作者
Maria Assunta Zocco, Enrico Di Stasio, Raimondo De Cristofaro, Marialuisa Novi, Maria Elena Ainora, Francesca Ponziani, Laura Riccardi, Stefano Lancellotti, Angelo Santoliquido, Roberto Flore, Maurizio Pompili, Gian Lodovico Rapaccini, Paolo Tondi, Giovanni Battista Gasbarrini, Raffaele Landolfi, Antonio Gasbarrini
发表日期
2009/10/1
期刊
Journal of hepatology
卷号
51
期号
4
页码范围
682-689
出版商
Elsevier
简介
BACKGROUND/AIMS
Prognostic scores currently used in cirrhotic patients do not include thrombotic risk factors (TRFs). Predicting factors of portal vein thrombosis (PVT) development are still unknown. We wanted to describe TRFs as a function of liver disease severity using the MELD score and assess the role of local and systemic TRFs as predictors of PVT development in cirrhotic patients.
METHODS
One hundred consecutive patients with liver cirrhosis were included in the study. TRFs, D-dimers, MELD score, portal vein patency and flow velocity were evaluated in all subjects at baseline and every 6 months thereafter. Variables able to predict PVT development within 1 year were identified by means of multiple logistic regression.
RESULTS
The plasma levels of protein C and antithrombin were lower and the concentration of D-dimers was higher in patients with advanced disease. Plasma levels of antithrombin …
引用总数
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