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To propose an appropriate nitrogen application mode and suitable drip irrigation lateral spacing, a field experiment was conducted during 2017–2018 and 2018–2019 growing seasons to quantify the different drip irrigation lateral spacings and nitrogen fertigation strategies effects on winter wheat growth, yield, and water use efficiency (WUE) in the North China Plain (NCP). The experiment consisted of three drip irrigation lateral spacing (LS) (40, 60, and 80 cm, referred to as D₄₀, D_60, and D₈₀ respectively) and three percentage splits of nitrogen application modes (NAM) (basal and top dressing application ratio as 50:50 (N_50:50), 25:75 (N_25:75), and 0:100 (N_0-100) respectively). The experimental findings depicted that yield and its components, and WUE were markedly affected by LS and NAM. Fertigation of winter wheat at N_25:75 NAM notably (P<0.05) increased the grain yield by 4.88%, 1.83% and 8.03%, 4.61%, and WUE by 3.10%, 3.18% and 5.37%, 7.82%, compared with those at NAM N_50:50 and N_0:100 in 2017–2018 and 2018–2019 growing seasons, respectively. LS D₄₀ appeared very fruitful in terms of soil moisture and nitrogen distribution, WUE, grain yield, and yield components than that of other LS levels. The maximum grain yield (8.73 and 9.40 t ha^-1) and WUE (1.70 and 1.95 kg m^-3) were obtained under D₄₀N_25:75 during both growing seasons, which mainly due to that all main yield components in D₄₀N_25:75 treatment, such as spikes per unit area, 1000-grain weight, and grains per spike were significantly higher as compared to other treatments. The outcomes of this research may provide a scientific basis of lateral spacing …