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High‐resolution isotropic T₂ mapping of the human brain with multi‐echo spin‐echo (MESE) acquisitions is challenging. When using a 2D sequence, the resolution is limited by the slice thickness. If used as a 3D acquisition, specific absorption rate limits are easily exceeded due to the high power deposition of nonselective refocusing pulses. A method to reconstruct 1‐mm³ isotropic T₂ maps is proposed based on multiple 2D MESE acquisitions. Data were undersampled (10‐fold) to compensate for the prolonged scan time stemming from the super‐resolution acquisition.

The proposed method integrates a classical super‐resolution with an iterative model‐based approach to reconstruct quantitative maps from a set of undersampled low‐resolution data. The method was tested on numerical and multipurpose phantoms, and in vivo data. T₂ values were assessed with a region‐of …