作者
Gian Franco Piredda, Samuele Caneschi, Tom Hilbert, Gabriele Bonanno, Arun Joseph, Karl Egger, Jessica Peter, Stefan Klöppel, Elisabeth Jehli, Matthias Grieder, Johannes Slotboom, David Seiffge, Martina Goeldlin, Robert Hoepner, Tom Willems, Serge Vulliemoz, Margitta Seeck, Punith B Venkategowda, Ricardo A Corredor Jerez, Bénédicte Maréchal, Jean‐Philippe Thiran, Roland Wiest, Tobias Kober, Piotr Radojewski
发表日期
2023/4
期刊
Magnetic resonance in medicine
卷号
89
期号
4
页码范围
1601-1616
简介
Purpose
Studies at 3T have shown that T1 relaxometry enables characterization of brain tissues at the single‐subject level by comparing individual physical properties to a normative atlas. In this work, an atlas of normative T1 values at 7T is introduced with 0.6 mm isotropic resolution and its clinical potential is explored in comparison to 3T.
Methods
T1 maps were acquired in two separate healthy cohorts scanned at 3T and 7T. Using transfer learning, a template‐based brain segmentation algorithm was adapted to ultra‐high field imaging data. After segmenting brain tissues, volumes were normalized into a common space, and an atlas of normative T1 values was established by modeling the T1 inter‐subject variability. A method for single‐subject comparisons restricted to white matter and subcortical structures was developed by computing Z‐scores. The comparison was applied to eight patients scanned at both …
引用总数
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GF Piredda, S Caneschi, T Hilbert, G Bonanno… - Magnetic resonance in medicine, 2023