作者
Ahmad Shahba, A Riaz Ahmed, K Mohsin, S Ibrahim Abdel-Rahman, F Kaed Alanazi
发表日期
2017/3/1
期刊
Die Pharmazie-An International Journal of Pharmaceutical Sciences
卷号
72
期号
3
页码范围
143-151
出版商
Avoxa-Mediengruppe Deutscher Apotheker GmbH
简介
Self-nanoemulsifying drug delivery systems (SNEDDS) offer an efficient choice to improve the poor dissolution and erratic bioavailability of poorly-water soluble drugs. However, liquid SNEDDS experience some manufacturing and stability limitations. To overcome these limitations, the current study aims to investigate and optimize the solidification of cinnarizine (CN) liquid SNEDDS onto pellets by fluid bed coating. The study involved optimization of process and formulation variables. The coated self-nanoemulsifying pellets (SNEP) were characterized, their droplet size and dissolution profiles were compared to the corresponding liquid SNEDDS. Higher spray/microclimate air pressure led to minimal agglomeration and minimal spray drying. However, slight increase in inlet air volume above 35 m3/h led to extensive spray drying. The optimized coating formula included oleic acid/Imwitor308/Cremophor El (25/25/50 …
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