作者
Khalid F Alhasani, Mohsin Kazi, Mohamed Abbas Ibrahim, Ahmad A Shahba, Fars K Alanazi
发表日期
2019/7/18
期刊
International journal of nanomedicine
页码范围
5435-5448
出版商
Taylor & Francis
简介
Background
Ramipril (RMP) suffers from poor aqueous solubility along with sensitivity to mechanical stress, heat, and moisture. The aim of the current study is to improve RMP solubility and stability by designing solid self-nanoemulsifying drug delivery system (S-SNEDDS) as tablet.
Methods
The drug was initially incorporated in different liquid formulations (L-SNEDDS) which were evaluated by equilibrium solubility, droplet size, and zeta potential studies. The optimized formulation was solidified into S-SNEDDS powder by the adsorbent Syloid® and compressed into a self-nanoemulsifying tablet (T-SNEDDS). The optimized tablet was evaluated by drug content uniformity, hardness, friability, disintegration, and dissolution tests. Furthermore, pure RMP, optimized L-SNEDDS, and T-SNEDDS were enrolled in accelerated and long-term stability studies.
Results
Among various liquid formulations, F5 L-SNEDDS [capmul …
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KF Alhasani, M Kazi, MA Ibrahim, AA Shahba… - International journal of nanomedicine, 2019