作者
Enrique F Schisterman, Sunni L Mumford, Karen C Schliep, Lindsey A Sjaarda, Joseph B Stanford, Laurie L Lesher, Jean Wactawski-Wende, Anne M Lynch, Janet M Townsend, Neil J Perkins, Shvetha M Zarek, Michael Y Tsai, Zhen Chen, David Faraggi, Noya Galai, Robert M Silver
发表日期
2015/5/1
期刊
The Journal of Clinical Endocrinology & Metabolism
卷号
100
期号
5
页码范围
1785-1791
出版商
Oxford University Press
简介
Objective
The objective was to determine the effect of preconception-initiated daily low-dose aspirin (LDA; 81 mg/day) treatment on time to pregnancy in women with a history of pregnancy loss.
Design
This was a multicenter, block-randomized, double-blind, placebo-controlled trial. Participants were block-randomized by center and eligibility stratum.
Setting
The study was conducted at four U.S.A. medical centers (2007–2012).
Participants
Participants women aged 18–40 years actively attempting pregnancy, stratified by eligibility criteria: the “original” stratum, women with one loss <20 weeks' gestation during the previous year; and the “expanded” stratum, women with one or two previous losses of any gestational age regardless of time since loss.
Intervention
Daily LDA was compared with matching placebo for up …
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EF Schisterman, SL Mumford, KC Schliep, LA Sjaarda… - The Journal of Clinical Endocrinology & Metabolism, 2015