作者
Eva M Lonn, Salim Yusuf, Prabhat Jha, Terrence J Montague, Koon K Teo, Claude R Benedict, Bertram Pitt
发表日期
1994/10
来源
Circulation
卷号
90
期号
4
页码范围
2056-2069
简介
A ngiotensin-converting enzyme (ACE) inhibitors are commonly used drugs in the management of a variety of cardiovascular diseases. They are effective antihypertensive agents. 1-3 Early studies have demonstrated reductions in mortality and symptoms of heart failure in patients with severe congestive heart failure. 4 More recently, clinical trials have demonstrated reductions in mortality and in hospitalizations for heart failure when these agents were used in pa-tients with moderate left ventricular dysfunction, with and without overt heartfailure, further expanding the clinical value of these drugs in the management of patients with cardiac diseases. These benefits have been observed consistently in several trials, 5-7 in patients with ischemic and nonischemic causes for the left ventricular dysfunction and with or without recent myocardial infarction. The reductions in progressive heart failure and mortality in these …
引用总数
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