作者
Emmert Roberts, Vanessa Delgado Nunes, Sara Buckner, Susan Latchem, Margaret Constanti, Paul Miller, Michael Doherty, Weiya Zhang, Fraser Birrell, Mark Porcheret, Krysia Dziedzic, Ian Bernstein, Elspeth Wise, Philip G Conaghan
发表日期
2016/3/1
来源
Annals of the rheumatic diseases
卷号
75
期号
3
页码范围
552-559
出版商
BMJ Publishing Group Ltd
简介
Objectives
We conducted a systematic literature review to assess the adverse event (AE) profile of paracetamol.
Methods
We searched Medline and Embase from database inception to 1 May 2013. We screened for observational studies in English, which reported mortality, cardiovascular, gastrointestinal (GI) or renal AEs in the general adult population at standard analgesic doses of paracetamol. Study quality was assessed using Grading of Recommendations Assessment, Development and Evaluation. Pooled or adjusted summary statistics were presented for each outcome.
Results
Of 1888 studies retrieved, 8 met inclusion criteria, and all were cohort studies. Comparing paracetamol use versus no use, of two studies reporting mortality one showed a dose–response and reported an increased relative rate of mortality from 0.95 (0.92 to 0.98) to 1.63 (1.58 to 1.68). Of four studies reporting cardiovascular AEs, all …
学术搜索中的文章
E Roberts, VD Nunes, S Buckner, S Latchem… - Annals of the rheumatic diseases, 2016
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