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Several in vivo applications of dissolution dynamic nuclear polarization (DNP) require rapid successive injections of hyperpolarized substrates. Here we present the design and performance of a custom‐built multisample dissolution DNP setup for small animal research.

The DNP setup consists of a commercial wide‐bore magnet charged to 3.35 T, a cryostat, a 94‐GHz microwave source, and a custom‐built skeleton that accommodates four identical sample sticks. Each sample stick features a dissolver locked into the skeleton port and a lifter, which permits moving the sample cup out of the liquid helium bath for dissolution.

The dissolution of the first sample was triggered after 2 hours of polarization buildup during single‐shot operation of the cryostat. Thereafter, a time window of 75–90 min was available to dissolve the remaining three polarized samples. The average liquid state …