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Background

Cardiac magnetic resonance (CMR) perfusion imaging yields high diagnostic accuracy for the detection of coronary artery disease (CAD)[1]. However, standard 2D multi-slice CMR perfusion techniques only provide limited coverage and hence prohibit computation of myocardial ischemic burden. Recently, two single-center 3D CMR perfusion studies have proven highly diagnostic for the detection of CAD relative to quantitative coronary angiography (QCA)[2] and fractional flow reserve (FFR)[3]. The aim of our prospective multicenter study is to assess the diagnostic performance of 3D CMR perfusion imaging in comparison with FFR.

Methods

Five centers across Europe have been enrolled to acquire 3D CMR perfusion and FFR data in a total of 150 patients with suspected CAD. CMR 3D perfusion imaging employs 10-fold accelerated kt PCA [4] providing whole heart coverage with a spatial resolution of …