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PURPOSE: To 1) quantify hemispheric differences in structural properties of the corticospinal tract in patients with a history of ACLR, and 2) assess the relationship between excitability and corticospinal tract structure.

METHODS: Ten ACLR participants (age: 22.6±1.9 yrs; height: 166.3±7.5 cm; mass: 65.4±12.6 kg, months from surgery: 70.0±23.6) volunteered for this cross-sectional study. Corticospinal tract structure (volume; fractional anisotropy [FA]; axial diffusivity [AD]; radial diffusivity [RD]; mean diffusivity [MD]) was assessed using diffusion tensor imaging, and excitability was assessed using transcranial magnetic stimulation (motor evoked potentials [MEP]) for each hemisphere. Hemispheric differences were evaluated using paired samples t-tests. Pearson product moment correlational analyses were conducted on structural and excitability outcomes. Alpha level was set at p≤ 0.05.

RESULTS: The hemisphere …