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There has been a lack of success in using synthetic nerve guides to close long lesion gaps. However, new approaches in molecular design, synthesis and fabrication offer great promise. In this study, a 13.56 MHz inductively-coupled discharge plasma reactor with an ammonia and argon gas mix was used to modify the surfaces of synthetic, biodegradable copolyester poly(l-lactide-co-ε-caprolactone) (PLCL, 70:30 mol%) electrospun membranes. The presence of single bondNH₂ groups on the PLCL surface were revealed by Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS). Vibrational calculation of NH₃ adsorbed on the membrane surface of PLCL was determined through DFT calculations. Membranes of PLCL treated with NH₃ showed significantly greater hydrophilicities which were a consequence of the NH₃ plasma-induced polar groups. Treated membranes had …