作者
Fulton T Crews, Donita L Robinson, L Judson Chandler, Cindy L Ehlers, Patrick J Mulholland, Subhash C Pandey, Zachary A Rodd, Linda P Spear, H Scott Swartzwelder, Ryan P Vetreno
发表日期
2019/9
期刊
Alcoholism: clinical and experimental research
卷号
43
期号
9
页码范围
1806-1822
简介
The Neurobiology of Adolescent Drinking in Adulthood (NADIA) Consortium has focused on the impact of adolescent binge drinking on brain development, particularly on effects that persist into adulthood. Adolescent binge drinking is common, and while many factors contribute to human brain development and alcohol use during adolescence, animal models are critical for understanding the specific consequences of alcohol exposure during this developmental period and the underlying mechanisms. Using adolescent intermittent ethanol (AIE) exposure models, NADIA investigators identified long‐lasting AIE‐induced changes in adult behavior that are consistent with observations in humans, such as increased alcohol drinking, increased anxiety (particularly social anxiety), increased impulsivity, reduced behavioral flexibility, impaired memory, disrupted sleep, and altered responses to alcohol. These behavioral …
引用总数
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