作者
Donita L Robinson, Dawnya L Zitzman, Katherine J Smith, Linda P Spear
发表日期
2011/3/10
期刊
Neuroscience
卷号
176
页码范围
296-307
出版商
Pergamon
简介
Subsecond fluctuations in dopamine (dopamine transients) in the nucleus accumbens are often time-locked to rewards and cues and provide an important learning signal during reward processing. As the mesolimbic dopamine system undergoes dynamic changes during adolescence in the rat, it is possible that dopamine transients encode reward and stimulus presentations differently in adolescents. However, to date no measurements of dopamine transients in awake adolescents have been made. Thus, we used fast scan cyclic voltammetry to measure dopamine transients in the nucleus accumbens core of male rats (29–30 days of age) at baseline and with the presentation of various stimuli that have been shown to trigger dopamine release in adult rats. We found that dopamine transients were detectable in adolescent rats and occurred at a baseline rate similar to adult rats (71–72 days of age). However, unlike …
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