作者
Mark Jakob, Kariem Sharaf, Markus Schirmer, Martin Leu, Stefan Küffer, Mattis Bertlich, Friedrich Ihler, Frank Haubner, Martin Canis, Julia Kitz
发表日期
2021/3
期刊
Strahlentherapie und Onkologie
卷号
197
页码范围
231-245
出版商
Springer Berlin Heidelberg
简介
Purpose
Cancer stem cells (CSCs) are held accountable for the progress of head and neck squamous cell carcinoma (HNSCC). In the presented study, the authors evaluated the prognostic value of CSC markers in two particular HNSCC cohorts.
Methods
This two cohort study consisted of 85 patients with advanced stage HNSCC, treated with primary radio(chemo)therapy (pRCT), and 95 patients with HNSCC, treated with surgery and partially adjuvant radio(chemo)therapy. Overall survival (OS), disease-free survival (DFS), and disease-specific survival (DSS) were assessed. Samples were assessed for the expression of different molecular stem cell markers (ALDH1, BCL11B, BMI‑1, and CD44).
Results
In the pRCT cohort, none of the baseline patient and tumor features exhibited a statistically significant relation with …
学术搜索中的文章
M Jakob, K Sharaf, M Schirmer, M Leu, S Küffer… - Strahlentherapie und Onkologie, 2021