作者
Natalie Kappus, Bianca Weinstock-Guttman, Jesper Hagemeier, Cheryl Kennedy, Rebecca Melia, Ellen Carl, Deepa P Ramasamy, Mariya Cherneva, Jacqueline Durfee, Niels Bergsland, Michael G Dwyer, Channa Kolb, David Hojnacki, Murali Ramanathan, Robert Zivadinov
发表日期
2016/2/1
期刊
Journal of Neurology, Neurosurgery & Psychiatry
卷号
87
期号
2
页码范围
181-187
出版商
BMJ Publishing Group Ltd
简介
Background
Cardiovascular (CV) risk factors have been associated with changes in clinical outcomes in patients with multiple sclerosis (MS).
Objectives
To investigate the frequency of CV risks in patients with MS and their association with MRI outcomes.
Methods
In a prospective study, 326 patients with relapsing–remitting MS and 163 patients with progressive MS, 61 patients with clinically isolated syndrome (CIS) and 175 healthy controls (HCs) were screened for CV risks and scanned on a 3T MRI scanner. Examined CV risks included hypertension, heart disease, smoking, overweight/obesity and type 1 diabetes. MRI measures assessed lesion volumes (LVs) and brain atrophy. Association between individual or multiple CV risks and MRI outcomes was examined adjusting for age, sex, race, disease duration and treatment status.
Results
Patients with MS showed increased frequency of smoking (51.7% vs 36.5%, p …
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N Kappus, B Weinstock-Guttman, J Hagemeier… - Journal of Neurology, Neurosurgery & Psychiatry, 2016