作者
Jeffrey S Berger, Lucy Z Kornblith, Michelle N Gong, Harmony R Reynolds, Mary Cushman, Yu Cheng, Bryan J McVerry, Keri S Kim, Renato D Lopes, Bassel Atassi, Scott Berry, Grant Bochicchio, Murillo de Oliveira Antunes, Michael E Farkouh, Yonatan Greenstein, Erinn M Hade, Kristin Hudock, Robert Hyzy, Pooja Khatri, Andrei Kindzelski, Bridget-Anne Kirwan, Lisa Baumann Kreuziger, Patrick R Lawler, Eric Leifer, Jose Lopez-Sendon Moreno, Jose Lopez-Sendon, James F Luther, Lilia Nigro Maia, John Quigley, Robert Sherwin, Lana Wahid, Jennifer Wilson, Judith S Hochman, Matthew D Neal, Jonathan Newman, Mark Geraci, Aldo Maggioni, Hooman Kamel, Ewan C Goligher, Ryan Zarychanski, Brendan M Everett, Sean van Diepen, Gregoire Le Gal, Deborah M Siegal, Jean-Philippe Galanaud, Sheila Hegde, Yuri Kim, Natalia S Rost, Aneesh B Singhal, Aira Contreras, Stephanie Mavromichalis, Eduardo Iturrate, Margaret Gilsenan, Anna Naumova, Arlene Roberts, Julia Levine, Christine M Leeper, Derek C Angus, Mary Martinez, Jake Schreiber, Joshua Froess, Caroline E Stehle, Ashita Sai Vadlamudi, Frank Sciurba, Alison Morris, Edvin Music, Sophie de Brouwer, Emilie Perrin, Caroline Gombault, Sandra Bula, Michael Nelson, Céline Daelemans, Laurine Paraz, Michelle A Detry, Anna McGlothlin, Melanie Quintana, Amy Crawford, Danielle Sin, Elhaji Diene, Ewelina Gwiszcz, Isabelle Hogan, Alair Holden, Nancy Ringwood, Laura Fitzgerald, Haley Morin, Brenda Nunez-Garcia, Aaron E Kornblith, Carolyn M Hendrickson, Deanna Lee, Viet Nguyen, Shannon Broaddrick, Neha Atal, David T Huang, Renee Wunderly, Meredith Buxton, Tracey Roberts, Kelsey Linstrum, Amanda McNamara, Alexandra Weissman, Dylan Barbee, Emily Berryman, Jamey Frasure, Amy Sulken, Jéssica Natuline Ianof, Lilian Mazza, Julia Morata, Carolina Martins Cafarella, Mayra Akimi Suiama, Daniele de Lima Franco, Jorge Escobedo, Andrea Martinez, Pedro Ohara, Douglas Assis, Chiara Manzalini, Stefania Corsi, Gianluca Campo, Paula Prieto, Rocio Prieto, Shamila Garg, Ricardo Fonseco, Stacey Reese, Oluwayemisi Mohammed, Rowena Dolor, Thomas L Ortel, Cameron Wolfe, Michael Plump, Rahul Nair, William Nkemdirim, Jen-Ting Chen, Benjamin Galen, Ari Moskowitz, Norma Keller, Eugene Yuriditsky, James Horowitz, Alexander Hindenburg, Tamta Chkhikvadze, Lynnie Bassoli, Tibério Costa, Jose Luis López-Sendón Moreno, Fernando Rodriguez Jorge, Sebastian García Madrona, Raquel Morillo Guerrero, Macarena Alpañes Buesa, Rosa Nieto Royo, Raquel Besse Diaz, Sergio Diz Fariña, Andres Gonzalez García, Osvaldo da Silva Júnior, Cássia Pradela, Cláudio Jorge
发表日期
2022/1/18
期刊
Jama
卷号
327
期号
3
页码范围
227-236
出版商
American Medical Association
简介
Importance
Platelets represent a potential therapeutic target for improved clinical outcomes in patients with COVID-19.
Objective
To evaluate the benefits and risks of adding a P2Y12 inhibitor to anticoagulant therapy among non–critically ill patients hospitalized for COVID-19.
Design, Setting, and Participants
An open-label, bayesian, adaptive randomized clinical trial including 562 non–critically ill patients hospitalized for COVID-19 was conducted between February 2021 and June 2021 at 60 hospitals in Brazil, Italy, Spain, and the US. The date of final 90-day follow-up was September 15, 2021.
Interventions
Patients were randomized to a therapeutic dose of heparin plus a P2Y12 inhibitor (n = 293) or a therapeutic dose of heparin only (usual care) (n = 269) in a 1:1 ratio for 14 days or until hospital discharge, whichever was sooner. Ticagrelor was the preferred P2Y12 inhibitor.
Main Outcomes and Measures
The …
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