作者
Ph Maupas, F Barin, J-P Chiron, P Coursaget, A Goudeau, J Perrin, F Denis, I Diop Mar
发表日期
1981/2/7
期刊
The Lancet
卷号
317
期号
8215
页码范围
289-292
出版商
Elsevier
简介
Three doses of inactivated hepatitis B vaccine were given at one-month intervals to Senegalese children aged less than two years. A control group received diphtheria/tetanus/polio vaccine. Of those HB vaccine recipients who were seronegative before immunisation, 94·5% had a specific anti-HBs response. Anti-HBs of maternal origin did not interfere with the active immunisation. HB vaccine was without ill-effects, irrespective of hepatitis B marker status before immunisation. After twelve months' follow-up, the incidence of the HBsAg carrier state was reduced by 85% in susceptible children (p<0·0001).
引用总数
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