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We examined the cholesterol-lowering effects of a proprietary Chinese red-yeast-rice supplement in an American population consuming a diet similar to the American Heart Association Step I diet using a double-blind, placebo-controlled, prospectively randomized 12-wk controlled trial at a university research center.

We evaluated the lipid-lowering effects of this red-yeast-rice dietary supplement in US adults separate from effects of diet alone.

Eighty-three healthy subjects (46 men and 37 women aged 34–78 y) with hyperlipidemia [total cholesterol, 5.28–8.74 mmol/L (204–338 mg/dL); LDL cholesterol, 3.31–7.16 mmol/L (128–277 mg/dL); triacylglycerol, 0.62–2.78 mmol/L (55–246 mg/dL); and HDL cholesterol 0.78–2.46 mmol/L (30–95 mg/dL)] who were not being treated with lipid-lowering drugs participated. Subjects were treated with red yeast rice (2.4 g/d) or placebo and instructed to …