作者
Donald L Morton, John F Thompson, Alistair J Cochran, Nicola Mozzillo, Robert Elashoff, Richard Essner, Omgo E Nieweg, Daniel F Roses, Harald J Hoekstra, Constantine P Karakousis, Douglas S Reintgen, Brendon J Coventry, Edwin C Glass, He-Jing Wang
发表日期
2006/9/28
期刊
New England Journal of Medicine
卷号
355
期号
13
页码范围
1307-1317
出版商
Massachusetts Medical Society
简介
Background
We evaluated the contribution of sentinel-node biopsy to outcomes in patients with newly diagnosed melanoma.
Methods
Patients with a primary cutaneous melanoma were randomly assigned to wide excision and postoperative observation of regional lymph nodes with lymphadenectomy if nodal relapse occurred, or to wide excision and sentinel-node biopsy with immediate lymphadenectomy if nodal micrometastases were detected on biopsy.
Results
Among 1269 patients with an intermediate-thickness primary melanoma, the mean (±SE) estimated 5-year disease-free survival rate for the population was 78.3±1.6% in the biopsy group and 73.1±2.1% in the observation group (hazard ratio for death, 0.74; 95% confidence interval [CI], 0.59 to 0.93; P=0.009). Five-year melanoma-specific survival rates were similar in the two groups (87.1±1.3% and 86.6±1.6%, respectively). In the biopsy group, the …
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DL Morton, JF Thompson, AJ Cochran, N Mozzillo… - New England Journal of Medicine, 2006