作者
Alvin P Makohon-Moore, Evan J Lipson, Jody E Hooper, Amanda Zucker, Jungeui Hong, Craig M Bielski, Akimasa Hayashi, Collin Tokheim, Priscilla Baez, Rajya Kappagantula, Zachary Kohutek, Vladimir Makarov, Nadeem Riaz, Michael A Postow, Paul B Chapman, Rachel Karchin, Nicholas D Socci, David B Solit, Timothy A Chan, Barry S Taylor, Suzanne L Topalian, Christine A Iacobuzio-Donahue
发表日期
2021/3/1
期刊
Clinical Cancer Research
卷号
27
期号
5
页码范围
1516-1525
出版商
American Association for Cancer Research
简介
Purpose
Melanoma is a biologically heterogeneous disease composed of distinct clinicopathologic subtypes that frequently resist treatment. To explore the evolution of treatment resistance and metastasis, we used a combination of temporal and multilesional tumor sampling in conjunction with whole-exome sequencing of 110 tumors collected from 7 patients with cutaneous (n = 3), uveal (n = 2), and acral (n = 2) melanoma subtypes.
Experimental Design
Primary tumors, metastases collected longitudinally, and autopsy tissues were interrogated. All but 1 patient died because of melanoma progression.
Results
For each patient, we generated phylogenies and quantified the extent of genetic diversity among tumors, specifically among putative somatic alterations affecting therapeutic resistance.
Conclusions
In 4 patients who received …
学术搜索中的文章
AP Makohon-Moore, EJ Lipson, JE Hooper, A Zucker… - Clinical Cancer Research, 2021