作者
O Ates, HH Alp, I Caner, A Yildirim, A Tastekin, I Kocer, O Baykal
发表日期
2009/1
期刊
European journal of ophthalmology
卷号
19
期号
1
页码范围
80-85
出版商
SAGE Publications
简介
Purpose
This study examines the levels of oxidative damage in patients with retinopathy of prematurity (ROP).
Methods
Fifty patients were recruited with a birthweight below 1500 g or gestational age below 32 weeks. The cases were classified into those who developed ROP (n=25) and those without ROP (n=25). The authors obtained blood and urine samples from each infant, for measuring 8-hydroxy 2-deoxyguanosine (8-OHdG) and malondialdehyde (MDA) levels, at the time of the first examination at 4–6 postnatal weeks.
Results
A significant difference was observed in leukocyte and urine 8-OHdG levels in patients with ROP compared to those without ROP (p<0.001 for both). Similarly, a significant difference was observed in plasma and urine MDA levels in patients with ROP compared to those without ROP (p<0.001 for both). In addition, significant correlations were found between levels of 8-OHdG in leukocyte …
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