作者
Stephanie H Ameis, Jason P Lerch, Margot J Taylor, Wayne Lee, Joseph D Viviano, Jon Pipitone, Arash Nazeri, Paul E Croarkin, Aristotle N Voineskos, Meng-Chuan Lai, Jennifer Crosbie, Jessica Brian, Noam Soreni, Russell Schachar, Peter Szatmari, Paul D Arnold, Evdokia Anagnostou
发表日期
2016/12/1
期刊
American Journal of Psychiatry
卷号
173
期号
12
页码范围
1213-1222
出版商
American Psychiatric Association
简介
Objective
Neurodevelopmental disorders (NDDs) (attention deficit hyperactivity disorder [ADHD], autism spectrum disorder [ASD], and obsessive-compulsive disorder [OCD]) share genetic vulnerability and symptom domains. The authors present direct comparison of structural brain circuitry in children and adolescents with NDDs and control subjects and examine brain circuit-behavior relationships across NDDs using dimensional measures related to each disorder.
Method
Diffusion imaging and behavioral measures were acquired in 200 children and adolescents (ADHD: N=31; OCD: N=36; ASD: N=71; controls: N=62; mean age range: 10.3–12.6 years). Following Tract-Based Spatial Statistics, multigroup comparison of white matter indices was conducted, followed by pairwise comparisons. Relationships of fractional anisotropy with dimensional measures of inattention, social deficits, obsessive-compulsive …
学术搜索中的文章
SH Ameis, JP Lerch, MJ Taylor, W Lee, JD Viviano… - American Journal of Psychiatry, 2016