作者
Dongze Li, Wei Wei, Xun Ran, Jing Yu, Hui Li, Lizhi Zhao, Honglian Zeng, Yu Cao, Zhi Zeng, Zhi Wan
发表日期
2017/8/1
来源
Clinica Chimica Acta
卷号
471
页码范围
38-45
出版商
Elsevier
简介
Background
This study investigated the associations between lipoprotein-associated phospholipase A2 (Lp-PLA2) and the risks of coronary heart disease (CHD) and ischemic stroke (IS) in the general population.
Methods
PubMed, Embase, and the Cochrane Library databases were searched for prospective cohort studies published prior to June 2016. Multivariate-adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) for CHD and IS risks according to Lp-PLA2 activity or mass were extracted, pooled, and weighted using random-effects modeling.
Results
Twelve studies examining Lp-PLA2 activity or mass and long-term risks of CHD and IS were included. Combined HRs for CHD and IS risks for the highest category referring to lowest category of Lp-PLA2 were 1.46 (95% CI: 1.20–1.78, P < 0.001) and 1.58 (95% CI: 1.21–2.07, P = 0.001), respectively. The same patterns were observed for both mass and …
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D Li, W Wei, X Ran, J Yu, H Li, L Zhao, H Zeng, Y Cao… - Clinica Chimica Acta, 2017