作者
Dongze Li, Lizhi Zhao, Jing Yu, Wei Zhang, Rongsheng Du, Xin Liu, Ying Liu, You Chen, Rui Zeng, Yu Cao, Zhi Zeng, Zhiwei Zhao, Jiang Wu
发表日期
2017/2/1
来源
Clinica Chimica Acta
卷号
465
页码范围
22-29
出版商
Elsevier
简介
Background
Risk associations between lipoprotein-associated phospholipase A2 (Lp-PLA2) and adverse outcomes in patients with coronary heart disease (CHD) remain unclear. The aim of the meta-analysis was to investigate the association between Lp-PLA2 and prognosis of CHD.
Methods
PubMed and Embase were examined for prospective studies published before June 2016. Multivariate-adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) for the risk of adverse outcomes according to Lp-PLA2 activity or mass were extracted, pooled, and weighted using generic inverse-variance and random-effect modeling.
Results
Fifteen studies with 30,857 participants were included. Overall, higher Lp-PLA2 activity or mass was not significantly related to increased risk of long-term all-cause mortality. However, higher Lp-PLA2 activity or mass was independently associated with an increased risk of long-term …
学术搜索中的文章
D Li, L Zhao, J Yu, W Zhang, R Du, X Liu, Y Liu, Y Chen… - Clinica Chimica Acta, 2017