作者
Claudia Günther, Eva Martini, Nadine Wittkopf, Kerstin Amann, Benno Weigmann, Helmut Neumann, Maximilian J Waldner, Stephen M Hedrick, Stefan Tenzer, Markus F Neurath, Christoph Becker
发表日期
2011/9/15
期刊
Nature
卷号
477
期号
7364
页码范围
335-339
出版商
Nature Publishing Group UK
简介
Dysfunction of the intestinal epithelium is believed to result in the excessive translocation of commensal bacteria into the bowel wall that drives chronic mucosal inflammation in Crohn’s disease, an incurable inflammatory bowel disease in humans characterized by inflammation of the terminal ileum. In healthy individuals, the intestinal epithelium maintains a physical barrier, established by the tight contact of cells. Moreover, specialized epithelial cells such as Paneth cells and goblet cells provide innate immune defence functions by secreting mucus and antimicrobial peptides, which hamper access and survival of bacteria adjacent to the epithelium. Epithelial cell death is a hallmark of intestinal inflammation and has been discussed as a possible pathogenic mechanism driving Crohn’s disease in humans. However, the regulation of epithelial cell death and its role in intestinal homeostasis remain poorly understood …
学术搜索中的文章
C Günther, E Martini, N Wittkopf, K Amann… - Nature, 2011