作者
Arianna Nenci, Christoph Becker, Andy Wullaert, Ralph Gareus, Geert Van Loo, Silvio Danese, Marion Huth, Alexei Nikolaev, Clemens Neufert, Blair Madison, Deborah Gumucio, Markus F Neurath, Manolis Pasparakis
发表日期
2007/3/29
期刊
Nature
卷号
446
期号
7135
页码范围
557-561
出版商
Nature Publishing Group UK
简介
Deregulation of intestinal immune responses seems to have a principal function in the pathogenesis of inflammatory bowel disease,,,. The gut epithelium is critically involved in the maintenance of intestinal immune homeostasis—acting as a physical barrier separating luminal bacteria and immune cells, and also expressing antimicrobial peptides,,. However, the molecular mechanisms that control this function of gut epithelial cells are poorly understood. Here we show that the transcription factor NF-κB, a master regulator of pro-inflammatory responses,, functions in gut epithelial cells to control epithelial integrity and the interaction between the mucosal immune system and gut microflora. Intestinal epithelial-cell-specific inhibition of NF-κB through conditional ablation of NEMO (also called IκB kinase-γ (IKKγ)) or both IKK1 (IKKα) and IKK2 (IKKβ)—IKK subunits essential for NF-κB activation,,—spontaneously caused …
引用总数
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A Nenci, C Becker, A Wullaert, R Gareus, G Van Loo… - Nature, 2007