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The mouse dura mater, pia mater, and choroid plexus contain resident macrophages and dendritic cells (DCs). These cells participate in immune surveillance, phagocytosis of cellular debris, uptake of antigens from the surrounding cerebrospinal fluid and immune regulation in many pathologic processes. We used Cx₃cr1^gfp knock-in, CD11c-eYFP transgenic and bone marrow chimeric mice to characterize the phenotype, density and replenishment rate of monocyte-derived cells in the meninges and choroid plexus and to assess the role of the chemokine receptor CX₃CR1 on their number and tissue distribution. Iba-1⁺ major histocompatibility complex (MHC) Class II⁺ CD169⁺ CD68⁺ macrophages and CD11c⁺ putative DCs were identified in meningeal and choroid plexus whole mounts. Comparison of homozygous and heterozygous Cx₃cr1^gfp mice did not reveal CX₃CR1-dependancy on density …