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Hill, M. A., Herdman, M. T., Stevens, D. L., Jones, N. J., Thacker, J. and Goodhead, D. T. Relative Sensitivities of Repair-Deficient Mammalian Cells for Clonogenic Survival after α-Particle Irradiation. Radiat. Res. 162, 667–676 (2004).

The clonogenic survival of cells of the radiation-sensitive hamster cell lines irs1, irs2, irs3 and xrs5, representing different DNA repair pathways, was compared to that of their parent lines after α-particle irradiation. Measurements of nuclear area were made to calculate the probability of surviving a single α-particle traversal, the average number of lethal lesions per track and per unit dose, along with the “intrinsic radiosensitivity” of these cells, allowing for the potential of multiple lethal lesions per traversal. For all cell lines studied, α particles were found to be more biologically effective per unit absorbed dose than X rays at inducing cell inactivation. The repair-deficient cells …