作者
Malgorzata A Komor, Linda JW Bosch, Veerle MH Coupé, Christian Rausch, Thang V Pham, Sander R Piersma, Sandra Mongera, Chris JJ Mulder, Evelien Dekker, Ernst J Kuipers, Mark A van de Wiel, Beatriz Carvalho, Remond JA Fijneman, Connie R Jimenez, Gerrit A Meijer, Meike De Wit
发表日期
2020/3
期刊
The Journal of pathology
卷号
250
期号
3
页码范围
288-298
出版商
John Wiley & Sons, Ltd
简介
Screening to detect colorectal cancer (CRC) in an early or premalignant state is an effective method to reduce CRC mortality rates. Current stool‐based screening tests, e.g. fecal immunochemical test (FIT), have a suboptimal sensitivity for colorectal adenomas and difficulty distinguishing adenomas at high risk of progressing to cancer from those at lower risk. We aimed to identify stool protein biomarker panels that can be used for the early detection of high‐risk adenomas and CRC. Proteomics data (LC–MS/MS) were collected on stool samples from adenoma (n = 71) and CRC patients (n = 81) as well as controls (n = 129). Colorectal adenoma tissue samples were characterized by low‐coverage whole‐genome sequencing to determine their risk of progression based on specific DNA copy number changes. Proteomics data were used for logistic regression modeling to establish protein biomarker panels. In …
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MA Komor, LJW Bosch, VMH Coupé, C Rausch… - The Journal of pathology, 2020