作者
Robert J Mentz, Matthew J Chung, Mihai Gheorghiade, Peter S Pang, Mary J Kwasny, Andrew P Ambrosy, Muthiah Vaduganathan, Christopher M O'Connor, Karl Swedberg, Faiez Zannad, Marvin A Konstam, Aldo P Maggioni
发表日期
2012/12/1
期刊
American heart journal
卷号
164
期号
6
页码范围
884-892. e2
出版商
Mosby
简介
BACKGROUND
Heart failure (HF) complicated by atrial fibrillation/flutter (AF/AFL) is associated with worse outcomes. However, the clinical profile and outcomes of patients following hospitalization for HF with AF/AFL on initial electrocardiogram (ECG) has not been well studied.
METHODS
EVEREST was a randomized trial of vasopressin-2 receptor blockade, in addition to standard therapy, in 4133 patients hospitalized with HF with ejection fraction ≤40%. A post hoc analysis was performed comparing the clinical characteristics and outcomes [all-cause mortality and cardiovascular mortality/HF hospitalization] of patients with AF/AFL versus sinus rhythm (SR) on baseline ECG, which were centrally analyzed. Times to events were compared using log-rank tests and Cox regression models.
RESULTS
Of the 4133 patients, 1195 (29%) were classified with AF/AFL and 2071(50%) with SR. The remaining patients (21 …
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RJ Mentz, MJ Chung, M Gheorghiade, PS Pang… - American heart journal, 2012