作者
Helga B Salvesen, Nicola MacDonald, Andy Ryan, Ian J Jacobs, Eric D Lynch, Lars A Akslen, Soma Das
发表日期
2001/1/1
期刊
International journal of cancer
卷号
91
期号
1
页码范围
22-26
出版商
John Wiley & Sons, Inc.
简介
Loss of heterozygosity and mutations in the PTEN (MMAC1) tumor suppressor gene are frequent in endometrial carcinoma. Promoter hypermethylation has recently been identified as an alternative mechanism of tumor suppressor gene inactivation in cancer, but its importance in the PTEN gene in endometrial carcinoma is unknown. The purpose of our study was to assess the frequency of promoter methylation of the PTEN gene and to determine its correlation with clinicopathologic variables in a prospective and population‐based series of endometrial carcinomas with complete follow‐up. Presence of PTEN promoter methylation was seen in 26 of 138 patients (19%). Methylation was significantly associated with metastatic disease (p = 0.01) and a microsatellite unstable phenotype (p = 0.006). In conclusion, we find that PTEN promoter methylation is relatively frequent in endometrial carcinoma. Its association with …
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HB Salvesen, N MacDonald, A Ryan, IJ Jacobs… - International journal of cancer, 2001