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Accepted: 6 November 2016/Published online: 9 November 2016© Springer Science+ Business Media New York 2016 of the MVA pathway including HMGCoA reductase, MVA kinase and farnesyl diphosphate farnesyl transferase and p53 status in GBM. Adipose-tissue-derived mesenchymal stem cells (AT_MSCs) have been seen to promote the aggressive growth of co-cultured GBM cell. Moreover, highly vascularized tumors developed when AT-MSC and GBM were co-transplanted in vivo [2]. For this reason we should consider that the intrinsic lipid metabolic reprogramming in glioma development is not necessarily linked to tissue obesity. Glioma grows inside the brain rather than in the lining and is much more likely to be insensitive to adipokines, growth factors, steroid hormones and inflammatory cyto/chemokines released by the adipose tissue that are known to play a key role in the mechanisms linking …