查看文章

The Cancer Cell Line Encyclopedia 1 (CCLE) and Cancer Genome Project 2 (CGP) are two independent large-scale efforts to characterize genomes, mRNA expression, and anti-cancer drug dose–responses across cell lines, providing a public resource relating cellular biochemical context to drug sensitivity. A recent study 3 analysed correlations between reported dose–response metrics and found inconsistency between CCLE and CGP, thus questioning the validity of not only these, but also other current and future costly large-scale studies. Here, we examine two metrics of drug responsiveness (slope and area under the curve) that we derive from the original CCLE and CGP data, and find reasonable and statistically significant consistency. Our results revive confidence that the CCLE and CGP drug dose–response data are of sufficient quality for meaningful analyses. There is a Reply to this Comment by …