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Corticotropin-releasing factor (CRF), urocortin, sauvagine and urotensin I form the CRF family. These peptides bind with different affinities to two subtypes of CRF receptor (CRFR), CRFR1 and CFiFFi2. The latter exists as two splice variants, the neuronal CRFRZoc and the peripheral CRFRZB. CRFR is a G protein-dependent receptor which acts mainly through’G5 enhancing CAMP production. However, CFiFFi1 expressed in neutrophils of the spleen in response to immunologic stimulation and psychological stress does not seem to function through GS, as indicated by the inability of CRF to stimulate the CAMP production of CRFR1+” neutrophils. Besides the two receptors, a 37 kD CRF binding protein (CRF-BP) binds several CRF peptides with high affinity. CRFH and CFiF-BP do not share a common amino acid sequence representing the ligand binding site. In view of the unusually slow offrate of CRF—BP, it is …