作者
Vincent De Smet, Stefaan Verhulst, Liza Dewyse, Mina Kazemzadeh Dastjerd, Hendrik Reynaert, Georg Halder, Inge Mannaerts, Leo A van Grunsven
发表日期
2021/7/1
研讨会论文
International Liver Congress 2021-EASL
简介
Hepatic stellate cells (HSC) are the major scar forming cells in liver fibrosis. During liver fibrosis, quiescent, vitamin-A-storing, HSCs (qHSC) transdifferentiate to an activated myofibroblast-like phenotype (aHSC) and exert fibrotic characteristics. Despite great advances in our understanding of these cells at different stages of disease, HSC-targeting drugs are still not used in the clinic, leaving an unmet need.
学术搜索中的文章
V De Smet, S Verhulst, L Dewyse, MK Dastjerd… - International Liver Congress 2021-EASL, 2021