作者
Marie Billaud, Alexander W Lohman, Adam C Straub, Robin Looft-Wilson, Scott R Johnstone, Christina A Araj, Angela K Best, Faraaz B Chekeni, Kodi S Ravichandran, Silvia Penuela, Dale W Laird, Brant E Isakson
发表日期
2011/6/24
期刊
Circulation research
卷号
109
期号
1
页码范围
80-85
出版商
Lippincott Williams & Wilkins
简介
Rationale:
The coordination of vascular smooth muscle cell constriction plays an important role in vascular function, such as regulation of blood pressure; however, the mechanism responsible for vascular smooth muscle cell communication is not clear in the resistance vasculature. Pannexins (Panx) are purine-releasing channels permeable to the vasoconstrictor ATP and thus may play a role in the coordination of vascular smooth muscle cell constriction.
Objective:
We investigated the role of pannexins in phenylephrine- and KCl-mediated constriction of resistance arteries.
Methods and Results:
Western blot, immunohistochemistry, and immunogold labeling coupled to scanning and transmission electron microscopy revealed the presence of Panx1 but not Panx2 or Panx3 in thoracodorsal resistance arteries. Functionally, the contractile response of pressurized thoracodorsal resistance arteries to phenylephrine …
学术搜索中的文章
M Billaud, AW Lohman, AC Straub, R Looft-Wilson… - Circulation research, 2011